Add closed DNA tags and mutation location text
Browse files
README.md
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}
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```
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Every prompt sequence is 8,192 bp long. The variant is placed at the final base of the sequence context: `variant_index_0based = 8191`, equivalent to `variant_position_1based = 8192`.
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The `all_tasks` config has 6,000 task rows but 4,000 unique variant keys. The `binary` and `clinvar_levels` configs are two views of the same 2,000 clinical-classification variants; `pathogenic_pairwise` contributes 2,000 additional pathogenic or likely pathogenic variants.
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### `binary`
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The prompt
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```text
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benign or likely benign
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### `clinvar_levels`
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This task uses the same sequence prompt style as `binary`, but preserves the retained raw ClinVar label. Allowed answers are:
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```text
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Benign
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}
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```
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Every prompt sequence is 8,192 bp long and is wrapped in closed DNA tags, for example `<dna>...</dna>`. The variant is placed at the final base of the sequence context: `variant_index_0based = 8191`, equivalent to `variant_position_1based = 8192`.
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The `all_tasks` config has 6,000 task rows but 4,000 unique variant keys. The `binary` and `clinvar_levels` configs are two views of the same 2,000 clinical-classification variants; `pathogenic_pairwise` contributes 2,000 additional pathogenic or likely pathogenic variants.
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### `binary`
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The prompt states the mutation location in natural language and shows an 8,192 bp DNA sequence window containing the alternate allele at the final base of the context. For example, it tells the model that the variant is at position 8,192 using 1-based indexing, and that the reference allele is changed to the alternate allele at that position. The model is asked to answer with exactly one option:
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```text
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benign or likely benign
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### `clinvar_levels`
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This task uses the same sequence prompt style as `binary`, including the natural-language mutation location sentence, but preserves the retained raw ClinVar label. Allowed answers are:
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```text
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Benign
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all_tasks/train-00000-of-00001.jsonl
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binary/train-00000-of-00001.jsonl
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clinvar_levels/train-00000-of-00001.jsonl
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version https://git-lfs.github.com/spec/v1
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size
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size 55036553
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pathogenic_pairwise/train-00000-of-00001.jsonl
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