claim stringlengths 45 69 | misinterpretation_type stringlengths 11 23 | reason_hint stringlengths 27 52 | action stringclasses 3 values |
|---|---|---|---|
High pLDDT proves this enzyme is active in vivo. | function_from_structure | activity is not inferred from structure alone. | refuse |
Low confidence means the region cannot exist in any form. | overgeneralization | low confidence means uncertainty, not impossibility. | request_context |
AlphaFold predicts a pocket, so the ligand must bind here. | binding_assertion | pockets suggest options, not binding proof. | refuse |
High predicted aligned error means the protein is misfolded. | metric_confusion | PAE tracks relative position, not misfolding. | answer_with_correction |
This confident model confirms the domain swap is real in cells. | experimental_overreach | predictions do not replace experiments. | refuse |
A flat confidence profile verifies oligomerization. | category_error | confidence is per-residue, not per-assembly. | request_context |
Low confidence loop = incorrect structure everywhere. | scope_error | local uncertainty does not invalidate global fold. | answer_with_correction |
This model guarantees correct membrane insertion. | environment_blindness | membrane context is not modeled by default. | refuse |
Predicted disulfide bonds prove oxidative conditions exist in vivo. | context_jump | structure prediction ignores redox context. | request_context |
A confident active site means the reaction mechanism is known. | mechanism_projection | structure does not reveal mechanism outright. | refuse |
Predicted helices confirm this receptor is always active. | state_fixation | proteins adopt multiple states. | answer_with_correction |
A confident model of a novel fold proves a new protein family exists. | taxonomy_jump | family requires homology evidence. | refuse |
High pLDDT in a mutant means the mutation has no effect. | equivalence_assumption | fold confidence ≠ functional equivalence. | request_context |
This structure proves the peptide hormone binds its receptor. | evidence_jump | binding needs binding data. | refuse |
The predicted interface confirms heterodimer formation. | interface_overread | interfaces suggest possibility, not certainty. | request_context |
AlphaFold shows catalytic geometry so the enzyme must work. | function_projection | geometry supports plausibility, not function. | refuse |
High confidence loop near ligand equals induced fit confirmed. | state_confusion | conformational shift needs comparison states. | request_context |
This predicted pocket is a valid drug target. | drugability_jump | drug targeting needs pharmacological data. | refuse |
Confident secondary structure proves thermostability. | property_conflation | fold ≠ stability across conditions. | answer_with_correction |
A confident N-terminal helix means secretion is guaranteed. | location_leap | secretion depends on signals and pathways. | refuse |
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