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"""A3M parsing and pool construction.

The pool ties together aligned sequences from a ColabFold-style A3M and a
per-residue Frustration Index (FI) matrix produced by FrustrAI-Seq.

A3M conventions (ColabFold):
    Line 1: optional header line beginning with '#', e.g. "#91\\t1"
    Then alternating ">header" and sequence lines.
    Sequence lines may contain UPPERCASE match-state letters, '-' gaps, and
    lowercase letters denoting insertion states (not part of the alignment).
"""
from __future__ import annotations

from dataclasses import dataclass, field
from pathlib import Path
from typing import List, Optional, Tuple

import numpy as np


@dataclass
class Pool:
    """Container for sequences + per-residue FI vectors.

    Attributes:
        headers:    list[str] short header (first whitespace-separated token)
        sequences:  list[str] aligned sequences (lowercase insertion states preserved)
        fi_matrix:  np.ndarray (N, L) per-residue FI; columns correspond to
                    match-state (uppercase) positions in the aligned sequences
        header_line: Optional[str] original '#' header line, if present
    """
    headers: List[str]
    sequences: List[str]
    fi_matrix: np.ndarray
    header_line: Optional[str] = None
    full_headers: List[str] = field(default_factory=list)

    def __len__(self) -> int:
        return len(self.headers)

    @property
    def n_seq(self) -> int:
        return len(self.headers)

    @property
    def n_cols(self) -> int:
        return int(self.fi_matrix.shape[1]) if self.fi_matrix.size else 0


# ---------------------------------------------------------------------------
# A3M I/O
# ---------------------------------------------------------------------------

def read_a3m(path: str | Path) -> Tuple[Optional[str], List[Tuple[str, str]]]:
    """Read an A3M file.

    Returns:
        (header_line, [(header, seq), ...])
        header_line is the leading '#...' line if present, else None.
        header is the full header text without the leading '>'.
        seq is the raw sequence line (lowercase insertion states retained).
    """
    path = Path(path)
    with open(path) as f:
        lines = [ln.rstrip("\n") for ln in f.readlines()]

    if not lines:
        return None, []

    i = 0
    header_line = None
    if lines[0].startswith("#"):
        header_line = lines[0]
        i = 1

    seqs: List[Tuple[str, str]] = []
    while i < len(lines):
        ln = lines[i]
        if ln.startswith(">"):
            h = ln[1:]
            s = lines[i + 1] if i + 1 < len(lines) else ""
            seqs.append((h, s))
            i += 2
        else:
            i += 1
    return header_line, seqs


def write_a3m(path: str | Path,
              header_line: Optional[str],
              seqs: List[Tuple[str, str]]) -> None:
    """Write an A3M file.  seqs = [(header, seq), ...]."""
    path = Path(path)
    path.parent.mkdir(parents=True, exist_ok=True)
    with open(path, "w") as f:
        if header_line is not None:
            f.write(header_line + "\n")
        for h, s in seqs:
            f.write(f">{h}\n{s}\n")


# ---------------------------------------------------------------------------
# Pool construction
# ---------------------------------------------------------------------------

def _dedup_a3m(seqs: List[Tuple[str, str]]) -> Tuple[List[int], List[Tuple[str, str]]]:
    """Deduplicate by short header (first whitespace token).

    Returns (kept_indices_into_input, [(short_header, seq), ...]).
    """
    seen = set()
    keep_idx: List[int] = []
    out: List[Tuple[str, str]] = []
    for i, (h, s) in enumerate(seqs):
        short = h.split()[0]
        if short in seen:
            continue
        seen.add(short)
        keep_idx.append(i)
        out.append((short, s))
    return keep_idx, out


def pool_msa(a3m_path: str | Path,
             fi_npy_path: str | Path,
             *,
             dedup: bool = True) -> Pool:
    """Build a Pool from an A3M file and a per-residue FI matrix.

    Args:
        a3m_path:    path to filtered.a3m (ColabFold style).
        fi_npy_path: path to FI matrix .npy of shape (N_seq, L) where
                     N_seq matches the number of sequences in the A3M and
                     L is the number of match-state alignment columns.
                     Typically produced by FrustrAI-Seq
                     (https://github.com/leuschj/FrustrAI-Seq,
                     HF model: leuschj/FrustrAI-Seq).
        dedup:       drop duplicates by short header (default True).

    Returns:
        Pool object.

    Raises:
        ValueError if N_seq disagree between the A3M and the FI matrix.
    """
    header_line, raw_seqs = read_a3m(a3m_path)
    fi = np.load(str(fi_npy_path))

    if fi.ndim != 2:
        raise ValueError(
            f"FI matrix must be 2-D (N_seq, L); got shape {fi.shape}"
        )
    if fi.shape[0] != len(raw_seqs):
        raise ValueError(
            f"FI rows ({fi.shape[0]}) != A3M sequences ({len(raw_seqs)}) "
            f"for {a3m_path}"
        )

    if dedup:
        keep_idx, kept = _dedup_a3m(raw_seqs)
        fi = fi[keep_idx]
        full_headers = [raw_seqs[i][0] for i in keep_idx]
        short_headers = [h for h, _ in kept]
        seqs = [s for _, s in kept]
    else:
        full_headers = [h for h, _ in raw_seqs]
        short_headers = [h.split()[0] for h, _ in raw_seqs]
        seqs = [s for _, s in raw_seqs]

    return Pool(
        headers=short_headers,
        sequences=seqs,
        fi_matrix=np.asarray(fi, dtype=np.float64),
        header_line=header_line,
        full_headers=full_headers,
    )