add all trained checkpoints: main splits + norman perturbation ablations
Browse filesThis view is limited to 50 files because it contains too many changes. See raw diff
- .gitattributes +23 -0
- README.md +14 -5
- models/ablations/norman_perturbation/comp_map/config.json +28 -0
- models/ablations/norman_perturbation/comp_map/model.pt +3 -0
- models/ablations/norman_perturbation/comp_map/train_info.json +322 -0
- models/ablations/norman_perturbation/comp_map_semi/config.json +29 -0
- models/ablations/norman_perturbation/comp_map_semi/model.pt +3 -0
- models/ablations/norman_perturbation/comp_map_semi/train_info.json +322 -0
- models/ablations/norman_perturbation/comp_map_tan/config.json +29 -0
- models/ablations/norman_perturbation/comp_map_tan/model.pt +3 -0
- models/ablations/norman_perturbation/comp_map_tan/train_info.json +322 -0
- models/ablations/norman_perturbation/default/config.json +30 -0
- models/ablations/norman_perturbation/default/model.pt +3 -0
- models/ablations/norman_perturbation/default/train_info.json +322 -0
- models/ablations/norman_perturbation/frac_0.1/config.json +30 -0
- models/ablations/norman_perturbation/frac_0.1/model.pt +3 -0
- models/ablations/norman_perturbation/frac_0.1/train_info.json +322 -0
- models/ablations/norman_perturbation/frac_0.25/config.json +30 -0
- models/ablations/norman_perturbation/frac_0.25/model.pt +3 -0
- models/ablations/norman_perturbation/frac_0.25/train_info.json +322 -0
- models/ablations/norman_perturbation/frac_0.5/config.json +30 -0
- models/ablations/norman_perturbation/frac_0.5/model.pt +3 -0
- models/ablations/norman_perturbation/frac_0.5/train_info.json +322 -0
- models/ablations/norman_perturbation/frac_0.75/config.json +30 -0
- models/ablations/norman_perturbation/frac_0.75/model.pt +3 -0
- models/ablations/norman_perturbation/frac_0.75/train_info.json +322 -0
- models/ablations/norman_perturbation/match_batch_celltype/config.json +30 -0
- models/ablations/norman_perturbation/match_batch_celltype/model.pt +3 -0
- models/ablations/norman_perturbation/match_batch_celltype/train_info.json +322 -0
- models/ablations/norman_perturbation/match_celltype/config.json +30 -0
- models/ablations/norman_perturbation/match_celltype/model.pt +3 -0
- models/ablations/norman_perturbation/match_celltype/train_info.json +322 -0
- models/ablations/norman_perturbation/match_nearest/config.json +30 -0
- models/ablations/norman_perturbation/match_nearest/model.pt +3 -0
- models/ablations/norman_perturbation/match_nearest/train_info.json +322 -0
- models/ablations/norman_perturbation/match_ot/config.json +30 -0
- models/ablations/norman_perturbation/match_ot/model.pt +3 -0
- models/ablations/norman_perturbation/match_ot/train_info.json +322 -0
- models/ablations/norman_perturbation/match_random/config.json +30 -0
- models/ablations/norman_perturbation/match_random/model.pt +3 -0
- models/ablations/norman_perturbation/match_random/train_info.json +322 -0
- models/ablations/norman_perturbation/rep_gene_only/config.json +30 -0
- models/ablations/norman_perturbation/rep_gene_only/model.pt +3 -0
- models/ablations/norman_perturbation/rep_gene_only/train_info.json +322 -0
- models/ablations/norman_perturbation/rep_gene_pathway_op/config.json +30 -0
- models/ablations/norman_perturbation/rep_gene_pathway_op/model.pt +3 -0
- models/ablations/norman_perturbation/rep_gene_pathway_op/train_info.json +322 -0
- models/ablations/norman_perturbation/rep_op_only/config.json +30 -0
- models/ablations/norman_perturbation/rep_op_only/model.pt +3 -0
- models/ablations/norman_perturbation/rep_op_only/train_info.json +322 -0
.gitattributes
CHANGED
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@@ -33,3 +33,26 @@ saved_model/**/* filter=lfs diff=lfs merge=lfs -text
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*.zst filter=lfs diff=lfs merge=lfs -text
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*tfevents* filter=lfs diff=lfs merge=lfs -text
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models/replogle_k562/model.pt filter=lfs diff=lfs merge=lfs -text
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*.zst filter=lfs diff=lfs merge=lfs -text
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*tfevents* filter=lfs diff=lfs merge=lfs -text
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models/replogle_k562/model.pt filter=lfs diff=lfs merge=lfs -text
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+
models/ablations/norman_perturbation/comp_map/model.pt filter=lfs diff=lfs merge=lfs -text
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+
models/ablations/norman_perturbation/comp_map_semi/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/comp_map_tan/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/default/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/frac_0.1/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/frac_0.25/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/frac_0.5/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/frac_0.75/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/match_batch_celltype/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/match_celltype/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/match_nearest/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/match_ot/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/match_random/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/rep_gene_only/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/rep_gene_pathway_op/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/rep_op_only/model.pt filter=lfs diff=lfs merge=lfs -text
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models/ablations/norman_perturbation/rep_random_id/model.pt filter=lfs diff=lfs merge=lfs -text
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models/norman/cell/model.pt filter=lfs diff=lfs merge=lfs -text
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models/norman/combination/model.pt filter=lfs diff=lfs merge=lfs -text
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models/norman/perturbation/model.pt filter=lfs diff=lfs merge=lfs -text
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models/replogle_k562/cell/model.pt filter=lfs diff=lfs merge=lfs -text
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models/replogle_k562/gene/model.pt filter=lfs diff=lfs merge=lfs -text
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models/replogle_k562/perturbation/model.pt filter=lfs diff=lfs merge=lfs -text
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README.md
CHANGED
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@@ -64,10 +64,13 @@ conda run -n pivot_gears python scripts/gears_ranking.py
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## Models
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-
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- `models/norman/` -
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-
- `models/replogle_k562/` -
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each folder has `model.pt` (a plain torch state dict), `config.json` (the training config),
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and `train_info.json` (history + run info). loading needs the matching preprocessed dataset,
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from src.data.perturb_data import load_dataset
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from src.training.train import TrainConfig, make_model
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-
cfg = TrainConfig(**json.load(open("models/norman/config.json")))
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data = load_dataset(cfg.dataset)
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model = make_model(data, cfg, device="cpu")
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model.load_state_dict(torch.load("models/norman/model.pt", map_location="cpu"))
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model.eval()
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```
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## License
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MIT, Bryan Cheng 2026. See `LICENSE`.
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## Models
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Every model behind the paper is checkpointed under `models/`, and `scripts/train_all.py`
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retrains them from scratch with the same configs and seed, so the numbers reproduce.
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- `models/norman/{cell,perturbation,combination}/` - Norman 2019 (CRISPRa K562), one per split
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- `models/replogle_k562/{cell,perturbation,gene}/` - Replogle 2022 (CRISPRi K562), one per split
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- `models/ablations/norman_perturbation/` - the ablation variants (loss components, perturbation
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representation, training-data fraction, control-matching strategy), each a separate folder
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each folder has `model.pt` (a plain torch state dict), `config.json` (the training config),
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and `train_info.json` (history + run info). loading needs the matching preprocessed dataset,
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from src.data.perturb_data import load_dataset
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from src.training.train import TrainConfig, make_model
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cfg = TrainConfig(**json.load(open("models/norman/perturbation/config.json")))
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data = load_dataset(cfg.dataset)
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model = make_model(data, cfg, device="cpu")
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model.load_state_dict(torch.load("models/norman/perturbation/model.pt", map_location="cpu"))
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model.eval()
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```
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To retrain everything:
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```bash
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python scripts/train_all.py
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```
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## License
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MIT, Bryan Cheng 2026. See `LICENSE`.
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models/ablations/norman_perturbation/comp_map/config.json
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{
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"dataset": "norman",
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"embedding": "pca",
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"split": "perturbation",
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"rep_mode": "gene_op",
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"match": "batch",
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"d_pert": 64,
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"hidden": 512,
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"depth": 4,
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"dropout": 0.0,
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"lr": 0.001,
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"weight_decay": 1e-05,
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"batch_size": 1024,
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"epochs": 45,
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"lam_tan": 1.0,
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"lam_semi": 0.5,
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"lam_reg": 0.0001,
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"grad_clip": 5.0,
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"train_frac": 1.0,
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"lam_dist": 0.0,
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"n_dist_perts": 4,
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"dist_n": 64,
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"seed": 0,
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"device_index": 3,
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"components": [
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"map"
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]
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}
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models/ablations/norman_perturbation/comp_map/model.pt
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version https://git-lfs.github.com/spec/v1
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+
oid sha256:d0fc420348d3e9e4ed59f6f36529905fa760793fd9cb0112a74caf8f02a2ce3e
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+
size 3575254
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models/ablations/norman_perturbation/comp_map/train_info.json
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{
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"history": [
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+
{
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"map": 8.809403766904559,
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|
models/ablations/norman_perturbation/comp_map_semi/config.json
ADDED
|
@@ -0,0 +1,29 @@
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{
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|
models/ablations/norman_perturbation/comp_map_semi/model.pt
ADDED
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@@ -0,0 +1,3 @@
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|
models/ablations/norman_perturbation/comp_map_tan/config.json
ADDED
|
@@ -0,0 +1,29 @@
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{
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"dataset": "norman",
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| 3 |
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| 4 |
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"split": "perturbation",
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"map",
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| 27 |
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"tan"
|
| 28 |
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| 29 |
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|
models/ablations/norman_perturbation/comp_map_tan/model.pt
ADDED
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@@ -0,0 +1,3 @@
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version https://git-lfs.github.com/spec/v1
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|
models/ablations/norman_perturbation/default/config.json
ADDED
|
@@ -0,0 +1,30 @@
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| 1 |
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{
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"dataset": "norman",
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| 3 |
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| 5 |
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"tan",
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| 28 |
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"semi"
|
| 29 |
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]
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| 30 |
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|
models/ablations/norman_perturbation/default/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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version https://git-lfs.github.com/spec/v1
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size 3575254
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models/ablations/norman_perturbation/default/train_info.json
ADDED
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@@ -0,0 +1,322 @@
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|
models/ablations/norman_perturbation/frac_0.1/config.json
ADDED
|
@@ -0,0 +1,30 @@
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{
|
| 2 |
+
"dataset": "norman",
|
| 3 |
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|
| 4 |
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"split": "perturbation",
|
| 5 |
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|
| 6 |
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"match": "batch",
|
| 7 |
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|
| 8 |
+
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|
| 9 |
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|
| 10 |
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|
| 11 |
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|
| 12 |
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|
| 13 |
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|
| 14 |
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|
| 15 |
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|
| 16 |
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|
| 17 |
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|
| 18 |
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|
| 19 |
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|
| 20 |
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|
| 21 |
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|
| 22 |
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|
| 23 |
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| 24 |
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| 25 |
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|
| 26 |
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| 27 |
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|
| 28 |
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"semi"
|
| 29 |
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|
| 30 |
+
}
|
models/ablations/norman_perturbation/frac_0.1/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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| 1 |
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version https://git-lfs.github.com/spec/v1
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size 3575254
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models/ablations/norman_perturbation/frac_0.1/train_info.json
ADDED
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@@ -0,0 +1,322 @@
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models/ablations/norman_perturbation/frac_0.25/config.json
ADDED
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@@ -0,0 +1,30 @@
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{
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| 29 |
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|
models/ablations/norman_perturbation/frac_0.25/model.pt
ADDED
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@@ -0,0 +1,3 @@
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models/ablations/norman_perturbation/frac_0.5/config.json
ADDED
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@@ -0,0 +1,30 @@
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models/ablations/norman_perturbation/frac_0.5/model.pt
ADDED
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| 321 |
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|
| 322 |
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|
models/ablations/norman_perturbation/frac_0.75/config.json
ADDED
|
@@ -0,0 +1,30 @@
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{
|
| 2 |
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"dataset": "norman",
|
| 3 |
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"embedding": "pca",
|
| 4 |
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"split": "perturbation",
|
| 5 |
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"rep_mode": "gene_op",
|
| 6 |
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"match": "batch",
|
| 7 |
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|
| 8 |
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|
| 9 |
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|
| 10 |
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|
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|
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| 17 |
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| 18 |
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| 24 |
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| 25 |
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"components": [
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| 26 |
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"map",
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| 27 |
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"tan",
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| 28 |
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"semi"
|
| 29 |
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]
|
| 30 |
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|
models/ablations/norman_perturbation/frac_0.75/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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version https://git-lfs.github.com/spec/v1
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size 3575254
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models/ablations/norman_perturbation/frac_0.75/train_info.json
ADDED
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@@ -0,0 +1,322 @@
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|
models/ablations/norman_perturbation/match_batch_celltype/config.json
ADDED
|
@@ -0,0 +1,30 @@
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| 1 |
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{
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"dataset": "norman",
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| 3 |
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| 4 |
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"split": "perturbation",
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| 5 |
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| 6 |
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"tan",
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| 28 |
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|
| 29 |
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|
| 30 |
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|
models/ablations/norman_perturbation/match_batch_celltype/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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version https://git-lfs.github.com/spec/v1
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size 3575254
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models/ablations/norman_perturbation/match_batch_celltype/train_info.json
ADDED
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@@ -0,0 +1,322 @@
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| 1 |
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models/ablations/norman_perturbation/match_celltype/config.json
ADDED
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{
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models/ablations/norman_perturbation/match_celltype/model.pt
ADDED
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|
models/ablations/norman_perturbation/match_nearest/config.json
ADDED
|
@@ -0,0 +1,30 @@
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| 1 |
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{
|
| 2 |
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"dataset": "norman",
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| 3 |
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"embedding": "pca",
|
| 4 |
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"split": "perturbation",
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| 5 |
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"rep_mode": "gene_op",
|
| 6 |
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"match": "nearest",
|
| 7 |
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|
| 8 |
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|
| 9 |
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|
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| 25 |
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"components": [
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| 26 |
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"map",
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| 27 |
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"tan",
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| 28 |
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"semi"
|
| 29 |
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]
|
| 30 |
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|
models/ablations/norman_perturbation/match_nearest/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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version https://git-lfs.github.com/spec/v1
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size 3575254
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models/ablations/norman_perturbation/match_nearest/train_info.json
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|
models/ablations/norman_perturbation/match_ot/config.json
ADDED
|
@@ -0,0 +1,30 @@
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| 1 |
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{
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| 2 |
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"dataset": "norman",
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| 3 |
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"embedding": "pca",
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| 4 |
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"split": "perturbation",
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| 5 |
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"rep_mode": "gene_op",
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| 6 |
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"match": "ot",
|
| 7 |
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"map",
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| 27 |
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"tan",
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| 28 |
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"semi"
|
| 29 |
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]
|
| 30 |
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|
models/ablations/norman_perturbation/match_ot/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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version https://git-lfs.github.com/spec/v1
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size 3575254
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models/ablations/norman_perturbation/match_ot/train_info.json
ADDED
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@@ -0,0 +1,322 @@
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|
models/ablations/norman_perturbation/match_random/config.json
ADDED
|
@@ -0,0 +1,30 @@
|
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{
|
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|
| 3 |
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|
| 4 |
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"split": "perturbation",
|
| 5 |
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|
| 6 |
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|
| 7 |
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|
| 8 |
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|
| 9 |
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|
| 10 |
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|
| 11 |
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|
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|
| 13 |
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|
| 14 |
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|
| 15 |
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|
| 16 |
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|
| 17 |
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|
| 18 |
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|
| 19 |
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|
| 20 |
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|
| 21 |
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|
| 22 |
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|
| 23 |
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|
| 24 |
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| 25 |
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| 26 |
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| 27 |
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| 28 |
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"semi"
|
| 29 |
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|
| 30 |
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|
models/ablations/norman_perturbation/match_random/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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version https://git-lfs.github.com/spec/v1
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| 3 |
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size 3575254
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models/ablations/norman_perturbation/match_random/train_info.json
ADDED
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@@ -0,0 +1,322 @@
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|
models/ablations/norman_perturbation/rep_gene_only/config.json
ADDED
|
@@ -0,0 +1,30 @@
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| 1 |
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{
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| 2 |
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"dataset": "norman",
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| 3 |
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"embedding": "pca",
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| 4 |
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"split": "perturbation",
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| 5 |
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"rep_mode": "gene_only",
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| 6 |
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"match": "batch",
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| 7 |
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| 27 |
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"tan",
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| 28 |
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"semi"
|
| 29 |
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]
|
| 30 |
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|
models/ablations/norman_perturbation/rep_gene_only/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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version https://git-lfs.github.com/spec/v1
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size 3575254
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models/ablations/norman_perturbation/rep_gene_only/train_info.json
ADDED
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@@ -0,0 +1,322 @@
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|
models/ablations/norman_perturbation/rep_gene_pathway_op/config.json
ADDED
|
@@ -0,0 +1,30 @@
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| 1 |
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{
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"dataset": "norman",
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| 3 |
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"embedding": "pca",
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| 4 |
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"split": "perturbation",
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| 5 |
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"rep_mode": "gene_pathway_op",
|
| 6 |
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"match": "batch",
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| 7 |
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"d_pert": 64,
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| 27 |
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"tan",
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| 28 |
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"semi"
|
| 29 |
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]
|
| 30 |
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|
models/ablations/norman_perturbation/rep_gene_pathway_op/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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version https://git-lfs.github.com/spec/v1
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size 3580428
|
models/ablations/norman_perturbation/rep_gene_pathway_op/train_info.json
ADDED
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@@ -0,0 +1,322 @@
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| 321 |
+
"n_train_cells": 70866
|
| 322 |
+
}
|
models/ablations/norman_perturbation/rep_op_only/config.json
ADDED
|
@@ -0,0 +1,30 @@
|
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| 1 |
+
{
|
| 2 |
+
"dataset": "norman",
|
| 3 |
+
"embedding": "pca",
|
| 4 |
+
"split": "perturbation",
|
| 5 |
+
"rep_mode": "op_only",
|
| 6 |
+
"match": "batch",
|
| 7 |
+
"d_pert": 64,
|
| 8 |
+
"hidden": 512,
|
| 9 |
+
"depth": 4,
|
| 10 |
+
"dropout": 0.0,
|
| 11 |
+
"lr": 0.001,
|
| 12 |
+
"weight_decay": 1e-05,
|
| 13 |
+
"batch_size": 1024,
|
| 14 |
+
"epochs": 45,
|
| 15 |
+
"lam_tan": 1.0,
|
| 16 |
+
"lam_semi": 0.5,
|
| 17 |
+
"lam_reg": 0.0001,
|
| 18 |
+
"grad_clip": 5.0,
|
| 19 |
+
"train_frac": 1.0,
|
| 20 |
+
"lam_dist": 0.0,
|
| 21 |
+
"n_dist_perts": 4,
|
| 22 |
+
"dist_n": 64,
|
| 23 |
+
"seed": 0,
|
| 24 |
+
"device_index": 3,
|
| 25 |
+
"components": [
|
| 26 |
+
"map",
|
| 27 |
+
"tan",
|
| 28 |
+
"semi"
|
| 29 |
+
]
|
| 30 |
+
}
|
models/ablations/norman_perturbation/rep_op_only/model.pt
ADDED
|
@@ -0,0 +1,3 @@
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|
| 1 |
+
version https://git-lfs.github.com/spec/v1
|
| 2 |
+
oid sha256:9cc33d5588c4d93e120d2aef53f362e74e910f2ac1caa4ca6bf8a147e95353ad
|
| 3 |
+
size 3575254
|
models/ablations/norman_perturbation/rep_op_only/train_info.json
ADDED
|
@@ -0,0 +1,322 @@
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| 1 |
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